PROGNOSTIC VALUE OF EXON 11 DELETIONS IN GISTs

Br J Cancer. 2009 Jun 16. [Epub ahead of print]

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Prognosis and predictive value of KIT exon 11 deletion in GISTs.

Bachet JB, Hostein I, Le Cesne A, Brahimi S, Beauchet A, Tabone-Eglinger S, Subra F, Bui B, Duffaud F, Terrier P, Coindre JM, Blay JY, Emile JF.

[1] EA4340 'Epidémiologie et Oncogénesè des tumeurs digestives', Faculté de médecine PIFO, UVSQ, 9 boulevard d'Alembert, 78280 Guyancourt, France [2] Service de Gastroentérologie et Oncologie Digestive, Hôpital Ambroise Paré, APHP, 9 avenue Charles de Gaulle, 92100 Boulogne, France.

Background:KIT exon 11 mutations are observed in 60% of gastrointestinal stromal tumours (GIST). Exon 11 codes for residues Tyr568 and Tyr570, which play a major role in signal transduction and degradation of KIT. Our aim was to compare the outcome of patients with deletion of both Tyr568-570 (delTyr) and the most frequent deletion delWK557-558 (delWK).Methods:Pathology and clinical characteristics of 68 patients with delTyr (n=26) or delWK (n=42) were reviewed and compared.Results:GISTs with delTyr were more frequently extragastric than those with delWK (69 vs 26%, P<0.0005). n="14)" n="29)," p="0.92)." n="15)" n="21)" n="14)" n="22)," p="0.43).Conclusion:In">