HYPONATREMIA IN SMALL CELL LUNG CANCER

Lung Cancer. 2009 Jun 15. [Epub ahead of print]

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The occurrence of hyponatremia in SCLC and the influence on prognosis A retrospective study of 453 patients treated in a single institution in a 10-year period.

Hansen O, Sørensen P, Hansen KH.

Department of Oncology, R, Odense University Hospital, DK-5000 Odense C, Denmark.

Hyponatremia is often seen in SCLC, and is thought to be caused by the paraneoplastic syndrome SIADH. Variable results of the prognostic significance of low P-sodium (P-Na) have been reported. This study was performed to investigate the prognostic value of hyponatremia in SCLC. Data was obtained from files from 453 patients diagnosed with SCLC and treated at Odense University Hospital from 1995 to 2005 in which data on P-sodium was available. The standard chemotherapy was six cycles of carboplatin-etoposide. P-Na was <125meq/l p="0.0001)." p="0.027),">