CHEMORADIATION IN ELDERLY PATIENTS WITH HEAD-NECK CANCER

Head Neck. 2014 Dec 22. doi: 10.1002/hed.23961. [Epub ahead of print]

Trends in chemoradiation use in elderly patients with head and neck cancer: Changing treatment patterns with cetuximab.

Baxi SS1, O'Neill C, Sherman EJ, Atoria CL, Lee NY, Pfister DG, Elkin EB.

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Abstract

Background: Cetuximab was approved for use in chemoradiation (CTRT) for locally-advanced head and neck squamous cell carcinoma (HNSCC) in 2006. Methods: Among 3,705 patients with locally-advanced HNSCC identified in the linked Surveillance Epidemiology and End Results (SEER)-Medicare database, we assessed treatment trends including surgery, RT, CTRT and specific agents used in CTRT. We examined the influence of demographic and clinical characteristics on the likelihood of receiving CTRT before and after 2006. Results: Chemoradiation use increased from 29% of patients diagnosed in 2001 to 61% in 2009 (p<0 .0001="" 2006.="" 2006="" abstracttext="" after="" age="" agent.="" all="" and="" article="" associated="" become="" before="" but="" by="" cetuximab="" chemotherapies="" combinations="" commonly="" comorbidity="" compared="" conclusions:="" concurrent="" copyright.="" ctrt="" especially="" has="" have="" in="" increased="" is="" may="" most="" neither="" nor="" of="" older="" patients.="" platinum="" prior="" protected="" receipt="" reserved.="" rights="" score="" sicker="" since="" substantially="" the="" then="" this="" to="" use="" used="" was="" were="" with="">