PROGNOSIS OF GISTs WITH SYNCHRONOUS GASTRIC CANCER

World J Surg Oncol. 2014 Jan 31;12:25. doi: 10.1186/1477-7819-12-25.

Prognostic analysis of gastric gastrointestinal stromal tumor with synchronous gastric cancer.

Lin M, Lin JX, Huang CM1, Zheng CH, Li P, Xie JW, Wang JB, Lu J.

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Abstract

BACKGROUND:

Many patients with gastric gastrointestinal stromal tumor (GIST) and synchronous gastric cancer have been described, most in single case studies. We retrospectively investigated the clinicopathologic features and prognostic effects of gastric GIST in patients with synchronous gastric cancer.

METHODS:

The study enrolled 170 patients with gastric GIST, who had undergone complete surgical resection (R0) from January 2000 to December 2011. Forty-two patients had synchronous gastric cancer (CA Group), whereas 128 did not (Non-CA Group). The clinicopathologic features and potential prognostic factors in the two groups were compared.

RESULTS:

Patients in the CA Group had more obvious symptoms, but a lower rate of preoperative diagnosis of gastric GIST (P <0 .05="" 5-year="" age="" analysis="" and="" cancer.="" cancer="" cd117="" cd34="" cox="" diameter="" differed="" each="" expression="" factors="" gastric="" gender="" greatest="" groups="" imatinib="" in="" independent="" lower="" of="" oral="" overall="" p="" patients="" postoperative="" predictive="" predictors="" rate="" regression="" risk="" showed="" significantly="" stratification="" stratified="" survival="" synchronous="" than="" that="" the="" those="" tumor-associated="" tumor="" two="" ulcers="" univariate="" was="" were="" with="" without="">

CONCLUSIONS:

Gastric GIST with synchronous gastric cancer had a lower rate of preoperative diagnosis, with correct diagnosis often missed. Survival, however, depended primarily on the gastric cancer.