INDUCTION CHEMOTHERAPY FOR HEAD-NECK CANCER

Oral Oncol. 2014 Jan;50(1):52-8. doi: 10.1016/j.oraloncology.2013.08.007. Epub 2013 Sep 19.

Comparison of carboplatin-paclitaxel to docetaxel-cisplatin-5-flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and neck cancer.

Herman LC1, Chen L2, Garnett A3, Feldman LE2, Smith B3, Weichselbaum RR1, Spiotto MT4.

Author information

Abstract

OBJECTIVES:

In head and neck squamous cell carcinoma (HNSCC), docetaxel, cisplatin and 5-fluorouracil (TPF) has become an accepted induction chemotherapy regimen. However, carboplatin-paclitaxel (CT) regimens have shown comparable outcomes. Here, we compared the outcomes of patients treated with either TPF or CT as induction chemotherapy followed by definitive chemoradiation.

PATIENTS AND METHODS:

We performed a single-institution retrospective analysis of patients with Stage III-IV HNSCC. From a database of 803 patients, we identified 143 patients treated with TPF or CT induction chemotherapy between 1999 and 2012.

RESULTS:

53 patients and 90 patients received TPF or CT induction chemotherapy, respectively. The median follow-up was 18.9months. The 1year locoregional control was 80.5% for CT compared to 55.5% for TPF (HR 0.32, P=.0002). The 1year progression free survival was 73.2% for CT compared to 60.7% for TPF (HR 0.57; P=.02). On multivariable analysis, CT remained significant for LRC (HR 0.28; P=0.04). TPF induction chemotherapy was associated with worse renal toxicity as measured by peak creatinine increases during induction chemotherapy (P=0.001). TPF was also associated with a trend toward more chemotherapy dose reductions or changes in systemic agents during concurrent chemoradiation (43.4% for TPF vs. 27.8% for CT; P=0.06).

CONCLUSIONS:

Compared to TPF induction chemotherapy, CT induction chemotherapy had at least similar if not better LRC and PFS in patients while having less renal toxicity. Thus, CT induction chemotherapy may benefit patients with locally advanced HNSCC by facilitating adequate chemoradiation regimens that enhanced disease control.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

CT, FFDM, HNSCC, Head and neck cancer, Induction chemotherapy, KPS, Karnofsky performance status, LRC, MVA, OS, PF, PFS, RT, Radiation therapy, THFX, TPF, TPF protocol, UVA, carboplatin–paclitaxel, cisplatin, 5-fluorouracil, docetaxel, cisplatin, 5-fluoruracil, freedom from distant metastasis, head and neck squamous cell carcinoma, locoregional control, multivariate analysis, overall survival, paclitaxel, 5FU, hydroxyurea, progression free survival, radiotherapy, univariate analysis