STATINS LINKED TO MUSCULOSKELETAL INJURIES 

DALLAS, TX – The use of statins appears to be associated with an increased risk of musculoskeletal injuries, including an increased risk of dislocations, strains, and sprains, according to a new analysis^[1]. Researchers suggest the full range of musculoskeletal adverse events might not be fully known and that further studies are needed, especially in active individuals.

"These findings are concerning because starting statin therapy at a young age for primary prevention of cardiovascular diseases has been widely advocated," report Dr Ishak Mansi(VA North Texas Health Care System, Dallas) and colleagues in a paper published online June 3, 2013 in the Journal of the American Medical Association: Internal Medicine. "Moreover, the numbers needed to be exposed for one additional person to be harmed were 37 to 58 individuals for various outcomes."

The study included 6967 statin users propensity-matched with 6967 nonusers. Of the statin users, the majority was treated with simvastatin (73.5%) and approximately one-third had been prescribed maximum doses of the drugs, including simvastatin 80 mg, atorvastatin 80 mg, or rosuvastatin(Crestor, AstraZeneca) 40 mg. Simvastatin 80 mg is currently restricted on the US market because of concerns about muscle damage.

In the propensity-matched analysis, treatment with a statin was associated with a 19% increased risk of any type of musculoskeletal injury (p<0 .001="" 13="" 7="" 9="" a="" adjusted="" an="" analyses="" analysis.="" and="" arthropathies="" association="" at="" baseline.="" but="" comorbidities="" dislocations="" excluded="" first="" for="" higher="" in="" increased="" musculoskeletal="" not="" of="" osteoarthritis="" p="" pain="" patients="" propensity-matched="" risk="" significant="" sprains="" statistically="" strains="" that="" the="" then="" there="" toward="" trend="" two="" was="" with="">

In contrast, researchers observed no association between the number of years an individual took simvastatin and the risk of musculoskeletal injuries.

The group says that musculoskeletal adverse events with statins may represent a lesser known side effect of the drug class and should be studied further, especially in individuals who continue to be physically active. A better understanding of the full risks of statins will also "provide more complete data for cost/benefit and cost-effectiveness analyses of statin use," write Mansi et al.