CNS MYELOMA 

Br J Haematol. 2013 Jun 15. doi: 10.1111/bjh.12414. [Epub ahead of print]

Central nervous system involvement with multiple myeloma: long term survival can be achieved with radiation, intrathecal chemotherapy, and immunomodulatory agents.

Chen CI, Masih-Khan E, Jiang H, Rabea A, Cserti-Gazdewich C, Jimenez-Zepeda VH, Chu CM, Kukreti V, Trudel S, Tiedemann R, Tsang R, Reece DE.

Source

Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

Abstract

Involvement of the central nervous system (CNS) in multiple myeloma (MM) is a rare complication, with reported survival of <6 13="" 17="" 1999="" 2010="" 24="" 2="" 37="" 4="" 76="" 78="" 81="" 95="" a="" achieved="" agents="" aggressive="" alkylators="" alone="" and="" associated="" at="" auto-transplant="" be="" bortezomib="" brain="" but="" can="" cell="" characteristics="" chemotherapy="" ci:="" cisplatin-based="" cisplatin="" clinical="" cns="" collected.="" combination="" common="" confidence="" contiguous="" cranial="" cyclophosphamide="" december="" describes="" dexamethasone="" diagnosis="" disease="" doxorubicin="" etoposide="" evaluated="" experience="" factors="" from="" general="" had="" haematological="" highly="" however="" identifies="" ids="" imid-based="" imid-containing="" immunomodulatory="" in="" institution.="" institution="" interval="" intrathecal="" involvement="" irradiation="" is="" it="" january="" leptomeningeal="" leukemia="" long-term="" median:="" median="" mm="" months.="" months="" multi-dosing="" nbsp="" nine="" of="" only="" or="" our="" p="" parenchymal="" patients="" plasma="" plasmacytomas="" present="" prolonged="" radiation="" radiotherapy="" relapse="" report="" retrospectively="" skull="" spinal="" spread.="" suggesting="" survival.="" survival="" survivors="" systemic="" the="" therapies="" therapy.="" these="" this="" to="" treated="" treatment="" used="" various="" was="" were="" with="">