Sentinel Node Tumor Burden According to the Rotterdam Criteria Is the Most Important Prognostic Factor for Survival in Melanoma Patients: A Multicenter Study in 388 Patients With Positive Sentinel Nodes
van Akkooi AC, Nowecki ZI, Voit C, et al
Ann Surg. 2008;248:949-955
Summary
This study evaluated survival in patients with sentinel node-positive melanoma using information from a multicenter study. Three European centers combined data from 388 patients with sentinel node-positive melanoma to study survival in relation to the burden of melanoma within the sentinel node. Breslow thickness was a strong predictor of survival, but the most important survival factor was the extent of metastatic disease within the sentinel node. Overall survival in patients with micrometastatic disease (<> 0.1 mm, the mortality rate was 4-5 times greater than in patients with micrometastases.
Viewpoint
This study had sufficient power to state conclusively that patients with small deposits of melanoma cells in sentinel nodes (<>
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