BLADDER SMALL CELL CANCER

BJU Int. 2008 Dec 5. [Epub ahead of print]

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Small cell carcinoma of the urinary bladder: a 15-year retrospective review of treatment and survival in the Anglian Cancer Network.

Mukesh M, Cook N, Hollingdale AE, Ainsworth NL, Russell SG.

Department of Oncology, Addenbrooke's Hospital NHS Trust, Cambridge, UK.

OBJECTIVE To report the clinical experience and management of patients with small cell carcinoma (SCC) of the bladder, treated in the Anglia Cancer network from 1992 to 2007, and to review published studies, as SCC is a rare condition, accounting for <1% class="yshortcuts" id="lw_1229795529_11">response rate to chemotherapy is high but the overall prognosis is poor. Brain secondaries are less common than for SCC of the lung and currently the role of PCI is unclear. As there is no standard of care for these patients, they are treated according to local protocols. Further efforts should be made to develop more effective treatments and the role of PCI should be assessed in the setting of a clinical trial, in conjunction with other extrapulmonary SCCs.