Τρίτη, 10 Νοεμβρίου 2015

VIDE CHEMOTHERAPY FOR RHABDOID TUMOR

 2015 Oct 15. doi: 10.1002/pbc.25777. [Epub ahead of print]

Successful Treatment of Extra-Renal Noncerebral Rhabdoid Tumors with VIDE.

Abstract

Extra-renal noncerebral rhabdoid tumors (ERRTs) are highly aggressive and often lethal. An optimal chemotherapy regimen for ERRT remains undetermined. We report on three pediatric patients successfully treated with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE). Two of our patients who had metastatic or refractory disease have survived more than 2 years, one disease free without myeloablative megatherapy. The treatment with high-dose alkylator therapy is reported to have a beneficial effect on survival. A VIDE regimen containing high-dose ifosfamide is feasible and appears to prolong the survival of patients with ERRT. This regimen may be a promising option for ERRT treatment without myeloablative megatherapy.

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