Impact of adjuvant taxane-based chemotherapy on development of breast cancer-related lymphedema: results from a large prospective cohort.
Swaroop MN1,
Ferguson CM,
Horick NK,
Skolny MN,
Miller CL,
Jammallo LS,
Brunelle CL,
O'Toole JA,
Isakoff SJ,
Specht MC,
Taghian AG.
Abstract
Taxane-based chemotherapy for the treatment of breast cancer is associated with fluid retention in the extremities; however, its association with development of breast cancer-related lymphedema is unclear. We sought to determine if adjuvant taxane-based chemotherapy increased risk of lymphedema or mild swelling of the upper extremity. 1121 patients with unilateral breast cancer were prospectively screened for lymphedema with perometer measurements. Lymphedema was defined as a relative volume change (RVC) of ≥10 % from preoperative baseline. Mild swelling was defined as RVC 5- <10 1.14="" 1.56="" 1.63="" 2-year="" 2.15="" 29="" 5.27="" abstracttext="" adjuvant="" age="" an="" analyses="" analysis="" and="" are="" associated="" at="" axillary="" body="" both="" but="" by="" characteristics="" chemotherapy.="" chemotherapy="" clinicopathologic="" cohort="" compared="" comparison="" cox="" cumulative="" determine="" dissection="" docetaxel="" does="" experience="" factors.="" groups="" hazard="" higher="" however="" hr="" in="" incidence="" increased="" index="" into="" kaplan-meier="" lymph="" lymphedema.="" lymphedema="" mass="" may="" medical="" mild="" multivariate="" nbsp="" no="" node="" non-taxane="" not="" obtained="" of="" older="" on="" or="" overall="" p="" patients="" performed="" proportional="" rates="" receive="" receiving="" record="" respectively="" review.="" risk="" significant="" significantly="" subsequent="" surgery="" swelling="" taxane-based="" taxane="" the="" this="" those="" to="" translate="" treated="" via="" was="" were="" when="" who="" with="">
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