NEW YORK (Reuters Health) Oct 27 - Bisphenol A at nanomolar concentrations confers chemoresistance in breast cancer cells in culture, according to a report in the October 6th issue of Environmental Health Perspectives.
Bisphenol A is an additive in many plastic products, including drinking bottles and the lining of food cans, and has been in the news lately as a potential health hazard. It has been suspected to promote carcinogenesis, based on its structural similarity to diethylstilbestrol (DES), the authors explain, but few studies have examined its potential effects on chemotherapeutic efficacy.
Dr. Elizabeth W. LaPensee and colleagues from the University of Cincinnati, Ohio, investigated whether bisphenol A at low concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in estrogen receptor (ER)-alpha positive and negative breast cancer cells in vitro.
Decreases in cell viability after exposure of ER-alpha-positive breast cancer cells to doxorubicin, cisplatin, and vinblastine were completely or partially antagonized by 24-hour pretreatment with nanomolar doses of bisphenol A, the authors report.
Responses were similar in ER-alpha-negative breast cancer cells, the report indicates.
The protective effects of bisphenol A were not mediated by classical estrogen receptors, the researchers note. Instead, bisphenol A appeared to promote chemoresistance by altering anti-apoptotic proteins in the Bcl pathway.
"These data highlight a previously unrecognized function of bisphenol A in cancer management," the authors conclude, "thereby adding a strong support to the growing recognition of the adverse effects of bisphenol A on human health."
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