According to the American Cancer Society, the most common pediatric neoplasms are leukemia, brain and spinal cord tumors, neuroblastomas, Wilms tumors, and lymphoma, including both Hodgkin and non-Hodgkin.
“In Israel, all fertility interventions, which include in vitro fertilization and ovulation induction, are fully covered by insurance, enabling citizens of all backgrounds access to these treatments,” said Eyal Sheiner, MD, PhD, Vice Dean of the Ben-Gurion University of the Negev Faculty of Health Sciences, member of its Department of Obstetrics and Gynecology, and a physician at Soroka.
Of the 242,187 newborn infants in the study, 237,863 (98.3%) were conceived spontaneously; 2,603 (1.1%) were conceived after in vitro fertilization, and 1,721 (0.7%) were conceived after ovulation induction treatments.
During the follow-up period of approximately 10.6 years, 1,498 neoplasms (0.6%) were diagnosed. The incidence rate for neoplasms was highest among children after in vitro fertilization (1.5 of 1,000) and ovulation induction (1.0 of 1,000) as compared to that of naturally conceived children (0.59 of 1,000).
“The research concludes that the association between in vitro fertilization and total pediatric neoplasms and malignancies is significant,” Dr. Sheiner said. “With increasing numbers of offspring conceived after fertility treatments, it is important to follow up on their health.”